A POI "right" behind the eye is not optimal to my mind. The skull thickens to accommodate the eye socket there. I'd pick a POI nearer the base of the ear. The skull is thinner and you're likely to take the brain stem as well. Switch POI, not calibre.
I've been shooting squizzers for 30+ years with a .22 and they are more than up to the job out to 40yds.
I've done a similar thing with rabbit POI - many years ago I shifted it away from the eye and more towards the base of the ear. Seems to work well if you can pull it off.
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